Paired Kidney Exchange (PKE)
The Paired Kidney Exchange (PKE) module provides a complete and flexible tool for swapping previously incompatible patient/donor pairs. The data for calculating matched pairs are all found within the HistoTrac database — no more sending data to third party programs. Select the optimal chain length, determine the source of antibody testing used to rule out donor incompatibility, and establish the factors that influence the PKE score for each chain.
The PKE Benefits
The PKE module provides the data and programming required for matching sensitized patients with a compatible donor. As patient test data are updated, the matches can be re-run without sending new data to a third party system.
The match program provides the flexibility needed to use the criteria of your transplant program. Adjust the parameters for one patient that might be different from another.
The program can be run by the clinical staff or can be used within the laboratory. A report documents the chains created.
The Matching Algorithim
Not all transplant programs use the same matching protocol when selecting a donor for a patient. The HistoTrac PKE module provides choices at each of various match criteria:
- Source and strength of antibody specificities
- Level of match at selected loci
- ABO Matching vs. ABO compatibility
- Non-HLA factors like infectious disease
- Weight and age of donor for pediatric patients
- Use patient unacceptable specificities or use
MFI data with selected cutoff per locus for assessment against donor antigens.
- Adjust variance to allow a lower antibody level
at selected loci.
- Enable an alert for mismatched ABO pairs.
- Select HLA typing values from either serology or serological equivalents from molecular testing, depending on data present on your pairs.
The PKE Score
Each chain’s score is calculated based on user-defined rankings such as the length of time the patient has been waiting for a transplant, the patient’s antibody level, and the importance of HLA match between the pair members. The higher the score, the more difficult the patient is to transplant.
Score points for Days in Program.
Factor the CPRA into the score.
Give points for matching weighted differently at
Evaluate the scores to select the most difficult-to-transplant patient.